https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48706 30 minutes] IRR=1.11 [1.04, 1.19]) and fewer specialist attendances (IRR=0.91 [0.85, 0.97]) and were more likely to have an emergency GP attendance (OR=2.29 [2.05, 2.57]). There were no significant differences in the odds of having either a HA or CDM or using allied health services for women with and without dementia indicators. Conclusions: The overall use of services designed to improve the prevention and coordination of the care of older people with chronic conditions was low. Women with dementia were no more likely to access these services. Implications for public health: There is underuse of some primary and allied healthcare services designed for people with complex chronic conditions. These could be better used by women with dementia to improve the management of complex comorbidities (e.g. CDMs), to prevent the onset of disability (e.g. physiotherapy), and enhance needs assessment and service access (e.g. HAs).]]> Wed 29 Mar 2023 15:32:41 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53917 Wed 28 Feb 2024 15:39:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45212 Wed 26 Oct 2022 15:56:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47145 Wed 14 Dec 2022 15:27:34 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44101 Wed 13 Mar 2024 09:41:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50101 Wed 12 Jul 2023 14:18:32 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25913 Wed 11 Apr 2018 12:48:18 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30896 Wed 11 Apr 2018 12:43:29 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15100 Wed 11 Apr 2018 11:36:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10767 Wed 11 Apr 2018 10:09:10 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15216 Wed 11 Apr 2018 09:45:45 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35136 Wed 10 Nov 2021 15:04:22 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49272 50 years old) at follow-up. Data were drawn from the first and second waves of the World Health Organization's Study on global AGEing and adult health. Self-report data captured sleep duration over two nights, and five cognitive tests (immediate and delayed verbal recall, forward and backward digit span, and verbal fluency) were used to measure various cognitive domains and create a composite z-score of cognitive performance. Linear regressions were performed to assess associations between sleep length changes and cognitive decline, controlling for relevant lifestyle and health factors. Increased sleep durations at follow-up among individuals who reported intermediate sleep durations (6-9 h/night) at baseline were significantly associated with greater rates of decline in overall cognitive function. Longer sleepers also trended toward greater rates of decline for attention/working memory and executive function. This study suggests that long sleep durations are a risk factor for certain types of impaired cognition among older adults living in a middle-income country. These findings are clinically important given the growing rates of dementia and aging populations globally.]]> Wed 10 May 2023 12:10:15 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46075 Wed 06 Mar 2024 15:05:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48466 Wed 06 Mar 2024 14:28:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54633 Wed 06 Mar 2024 11:00:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45655 Wed 02 Nov 2022 15:45:00 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34333 Wed 02 Mar 2022 14:24:45 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47819 11.0 µmol/L (p = 0.012), cysteine levels were <255 µmol/L (p = 0.033) and serum folate was <22.0 nmol/L (p = 0.003; in males only). In females, dietary intake of total folate <336 µg/day (p=0.001), natural folate <270 µg/day (p = 0.011), and vitamin B2 < 1.12 mg/day (p = 0.028) was associated with an increased AD risk. These results support Hcy, Cys, and SF as useful biomarkers for AD, irrespective of APOE4 genotype and as such should be considered as part of screening and managing risk of AD.]]> Wed 01 Feb 2023 09:58:55 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36552 Tue 30 Jun 2020 12:45:46 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53477 Tue 28 Nov 2023 16:01:15 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54465 Tue 27 Feb 2024 14:04:51 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31136 Tue 24 Mar 2020 13:00:17 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50963 Tue 22 Aug 2023 11:46:07 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55370 Tue 21 May 2024 13:35:53 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37371 Tue 20 Oct 2020 14:31:08 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54367 Tue 20 Feb 2024 19:56:27 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40883 Tue 19 Jul 2022 14:52:21 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47035 Tue 13 Dec 2022 14:15:25 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53636 Tue 12 Dec 2023 16:00:49 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45999 Tue 08 Nov 2022 16:18:09 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45964 Tue 08 Nov 2022 13:30:15 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54123 Tue 06 Feb 2024 11:21:33 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32433 Tue 05 Jun 2018 14:58:41 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51326 Thu 31 Aug 2023 14:34:53 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45236 Thu 27 Oct 2022 13:45:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36906 Thu 16 Jul 2020 12:26:42 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43376 5 years. Conclusions: Use of potentially inappropriate medications in Australian nursing home residents with advanced dementia is common. A greater understanding of the rationale that underpins prescribing of medications is required.]]> Thu 15 Sep 2022 15:53:32 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51680 Thu 14 Sep 2023 15:52:08 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54812 Thu 14 Mar 2024 14:31:38 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38637 Thu 14 Mar 2024 08:30:25 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39908 Thu 14 Jul 2022 12:27:50 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23647 Thu 13 Oct 2016 11:33:45 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36055 Thu 13 Jan 2022 10:32:01 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42951 KCNJ2 gene involved in the transduction of sour taste have been linked to variations in sour taste and non-gustatory functions. However, relationships between sour taste genetics, mild cognitive impairment, and diet quality are yet to be elucidated. This study investigated the associations between the presence of the KCNJ2-rs236514 variant (A) allele, diet quality indices, and mild cognitive impairment evaluated by the Mini-Mental State Examination (MMSE), in a secondary cross-sectional analysis of data from the Retirement Health & Lifestyle Study. Data from 524 elderly Australians (≥65y) were analyzed, using standard least squares regression and nominal logistic regression modeling, with demographic adjustments applied. Results showed that the presence of the KCNJ2-A allele is associated with increased proportions of participants scoring in the range indicative of mild or more severe cognitive impairment (MMSE score of ≤26) in the total cohort, and males. These associations remained statistically significant after adjusting for age, sex, and diet quality indices. The absence of association between the KCNJ2-A allele and cognitive impairment in women may be related to their higher diet quality scores in all indices. The potential link between sour taste genotype and cognitive impairment scores may be due to both oral and extra-oral functions of sour taste receptors. Further studies are required on the role and relationship of neurotransmitters, sour taste genotypes and sour taste receptors in the brain, and dietary implications, to identify potential risk groups or avenues for therapeutic or prophylactic interventions.]]> Thu 08 Sep 2022 14:04:41 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52237 Thu 05 Oct 2023 11:40:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30664 Thu 02 May 2019 11:11:55 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31576 Sat 24 Mar 2018 08:44:59 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7490 Sat 24 Mar 2018 08:37:45 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7491 Sat 24 Mar 2018 08:37:45 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7823 Sat 24 Mar 2018 08:37:38 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1462 Sat 24 Mar 2018 08:28:07 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1764 Sat 24 Mar 2018 08:27:36 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:2843 Sat 24 Mar 2018 08:27:12 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12249 Sat 24 Mar 2018 08:08:08 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18298 Sat 24 Mar 2018 08:04:27 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17262 Sat 24 Mar 2018 08:01:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21821 Sat 24 Mar 2018 07:58:43 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21468 N = 104) were randomly assigned to the experimental or control group. The experimental group received 12 sessions of group music therapy (two 30-min sessions per week for 6 weeks), and the control group received usual care. Data were collected 4 times: (1) 1 week before the intervention. ; (2) the 6th session of the intervention. ; (3) the 12th session of the intervention. ; (4) 1 month after the final session. Results: Group music therapy reduced depression in persons with dementia. Improvements in depression occurred immediately after music therapy and were apparent throughout the course of therapy. The cortisol level did not significantly decrease after the group music therapy. Cognitive function significantly improved slightly at the 6th session, the 12th session, and 1 month after the sessions ended; in particular, short-term recall function improved. The group music therapy intervention had the greatest impact in subjects with mild and moderate dementia. Conclusion: The group music intervention is a noninvasive and inexpensive therapy that appeared to reduce elders’ depression. It also delayed the deterioration of cognitive functions, particularly short-term recall function. Group music therapy may be an appropriate intervention among elderly persons with mild and moderate dementia.]]> Sat 24 Mar 2018 07:52:31 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18581 Sat 24 Mar 2018 07:50:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:258 Sat 24 Mar 2018 07:42:57 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27385 -6) was sought in 10,617 participants of European descent, 3811 African-Americans, and 1561 young adults. Results: rs4420638, near APOE, was associated with poorer delayed recall performance in discovery (p = 5.57 x 10^-10) and replication cohorts (p = 5.65 x 10^-8). This association was stronger for paragraph than word list delayed recall and in the oldest persons. Two associations with specific tests, in subsets of the total sample, reached genome-wide significance in combined analyses of discovery and replication (rs11074779 [HS3ST4], p = 3.11 x 10^-8, and rs6813517 [SPOCK3], p = 2.58 x 10^-8) near genes involved in immune response. A genetic score combining 58 independent suggestive memory risk variants was associated with increasing Alzheimer disease pathology in 725 autopsy samples. Association of memory risk loci with gene expression in 138 human hippocampus samples showed cis-associations with WDR48 and CLDN5, both related to ubiquitin metabolism. Conclusions: This largest study to date exploring the genetics of memory function in ~40,000 older individuals revealed genome-wide associations and suggested an involvement of immune and ubiquitin pathways.]]> Sat 24 Mar 2018 07:34:11 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27391 Sat 24 Mar 2018 07:34:10 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27641 Sat 24 Mar 2018 07:34:04 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25737 Clinical practice guidelines and principles of care for people with dementia (Guidelines) was recently approved by the National Health and Medical Research Council (NHMRC). Objective: This article describes the recommendations within the Guidelines that are of greatest relevance to GPs, including those addressing diagnosis, living well, managing behavioural and psychological symptoms, supporting carers, and the palliative approach. Discussion: The Guidelines synthesise current evidence in dementia care and emphasise: timely diagnosis; encouraging the person with dementia to exercise, eat well and keep doing as much for themselves as possible; supporting and training carers to provide care; and reducing prescription of potentially harmful medications where possible.]]> Sat 24 Mar 2018 07:30:43 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26028 Sat 24 Mar 2018 07:26:29 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22592 Sat 24 Mar 2018 07:15:58 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37185 Mon 31 Aug 2020 10:58:00 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54964 Mon 25 Mar 2024 12:03:55 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44734 Mon 24 Oct 2022 08:28:26 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32554 Mon 23 Sep 2019 13:14:39 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32851 Mon 23 Sep 2019 12:33:59 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49545 Mon 22 May 2023 08:45:20 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49537 Mon 22 May 2023 08:38:22 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53955 Mon 22 Jan 2024 17:03:26 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46409 Mon 21 Nov 2022 11:52:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18663 Mon 20 Jul 2015 17:06:14 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47386 Mon 16 Jan 2023 15:24:52 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46183 Mon 14 Nov 2022 10:13:02 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50949 Mon 14 Aug 2023 14:35:52 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44198 Mon 10 Oct 2022 15:07:31 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55061 Mon 08 Apr 2024 12:31:44 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50759 Mon 07 Aug 2023 14:29:32 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45642 Mon 06 Feb 2023 15:23:10 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50078 Fri 30 Jun 2023 15:18:13 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50568 Fri 28 Jul 2023 11:34:42 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52789 Fri 27 Oct 2023 10:22:21 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39219 HFE p.C282Y variant can cause iron overload and hemochromatosis, mostly in homozygous males. Objective: To estimate p.C282Y associations with brain MRI features plus incident dementia diagnoses during follow-up in a large community cohort. Methods: UK Biobank participants with follow-up hospitalization records (mean 10.5 years). MRI in 206 p.C282Y homozygotes versus 23,349 without variants, including T2* measures (lower values indicating more iron). Results: European ancestry participants included 2,890 p.C282Y homozygotes. Male p.C282Y homozygotes had lower T2* measures in areas including the putamen, thalamus, and hippocampus, compared to no HFE mutations. Incident dementia was more common in p.C282Y homozygous men (Hazard Ratio HR = 1.83; 95% CI 1.23 to 2.72, p = 0.003), as was delirium. There were no associations in homozygote women or in heterozygotes. Conclusion: Studies are needed of whether early iron reduction prevents or slows related brain pathologies in male HFE p.C282Y homozygotes.]]> Fri 27 May 2022 11:37:31 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46580 Fri 25 Nov 2022 13:39:35 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55388 Fri 24 May 2024 10:34:16 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48100 Fri 24 Feb 2023 15:31:10 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36850 Fri 17 Jul 2020 09:45:21 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43404 Fri 16 Sep 2022 10:12:31 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49953 Fri 16 Jun 2023 13:49:41 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44466 Fri 14 Oct 2022 08:43:35 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48915 Fri 14 Apr 2023 16:30:13 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48892 Fri 14 Apr 2023 15:30:55 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47296 Fri 13 Jan 2023 10:45:52 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44932 Fri 10 Mar 2023 17:49:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51370 Fri 01 Sep 2023 13:43:45 AEST ]]>